Tomoi M, Maeda M, Yoshida M, Yamada H, Kawamura Y, Hayashi N, Ishii Y, Kubota T
Department of Radiology, Fukui Medical University, Japan.
Radiat Med. 1999 May-Jun;17(3):195-9.
The purpose of this study was to assess tumor vascularity of the brain by dynamic susceptibility contrast (DSC) MR imaging and to determine whether this method is clinically useful for monitoring radiation effects on brain tumors. We, furthermore, compared DSC MR imaging with single-photon emission computed tomography (SPECT) using technetium-99m diethylene-triamine-pentaacetic acid human serum albumin (99mTc-HSA-D) in the assessment of tumor vascularity in a limited numbers of cases.
Twelve patients with various kinds of brain tumors were studied. DSC MRI was performed on all patients before and after radiation therapy. SPECT using 99mTc-HSA-D was also performed in five patients. The rate of change in tumor blood volume in response to radiation therapy was evaluated with DSC MRI and SPECT. The rate of change in tumor volume in response to radiation was also measured.
Ten patients were successfully studied. The rate of change in tumor blood volume correlated well between DSC MRI and SPECT. There was no significant correlation between the rates of change for tumor blood volume and tumor volume. Changes in tumor vascularity preceded the reduction in tumor volume seen following radiotherapy.
DSC MRI provides information regarding radiation effects on tumor vessels that is not available with conventional MRI.
本研究旨在通过动态对比增强磁共振成像（DSC-MRI）评估脑肿瘤的血管情况，并确定该方法在监测脑肿瘤放疗效果方面是否具有临床实用性。此外，我们还在有限数量的病例中，将DSC-MRI与使用锝-99m二乙烯三胺五乙酸人血清白蛋白（99mTc-HSA-D）的单光子发射计算机断层扫描（SPECT）在评估肿瘤血管方面进行了比较。
对12例患有各种脑肿瘤的患者进行了研究。所有患者在放疗前后均接受了DSC-MRI检查。5例患者还接受了使用99mTc-HSA-D的SPECT检查。通过DSC-MRI和SPECT评估放疗后肿瘤血容量的变化率。同时也测量了放疗后肿瘤体积的变化率。
成功对10例患者进行了研究。DSC-MRI和SPECT测得的肿瘤血容量变化率具有良好的相关性。肿瘤血容量变化率与肿瘤体积变化率之间无显著相关性。放疗后肿瘤血管的变化先于肿瘤体积的缩小。
DSC-MRI能够提供传统MRI无法获得的有关放疗对肿瘤血管影响的信息。
