Karjalainen J, Kujala U M, Stolt A, Mäntysaari M, Viitasalo M, Kainulainen K, Kontula K
Central Military Hospital, Helsinki, Finland.
J Am Coll Cardiol. 1999 Aug;34(2):494-9. doi: 10.1016/s0735-1097(99)00199-0.
We studied whether left ventricular mass in athletes associates with polymorphisms in genes encoding components of the renin-angiotensin system.
Adaptive left ventricular hypertrophy is a feature of the athlete's heart. However, similarly training athletes develop left ventricular mass to a different extent, suggesting that genetic factors may modulate heart size.
We measured left ventricular mass by echocardiography in 50 male and 30 female elite endurance athletes aged 25 +/- 4 (mean +/- SD) years. Deoxyribonucleic acid samples were prepared for genotyping of angiotensinogen (AGT) gene M235T polymorphism, angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and angiotensin II type 1 receptor (AT1) gene A1166C polymorphism.
The AGT gene M235T genotypes were significantly associated with left ventricular mass independently of blood pressure in both genders (p = 0.0036 for pooled data). TT homozygotes had greater mass compared with MM homozygotes in both men (147 +/- 12 g/m vs. 132 +/- 15 g/m, p = 0.032) and women (121 +/- 12 g/m vs. 101 +/- 13 g/m, p = 0.019). There was a gender difference in the relation between myocardial mass and AGT genotype, MT heterozygotes resembling MM homozygotes among women and TT homozygotes among men. The other studied gene polymorphisms were not associated with left ventricular mass.
Angiotensinogen gene M235T polymorphism is associated with the variability in left ventricular hypertrophy induced by endurance training, with athletes homozygous for the T allele having the largest hearts. We found no association between ACE gene I/D or AT1 gene A1166C polymorphisms and left ventricular mass.
我们研究了运动员左心室质量是否与肾素 - 血管紧张素系统组成成分编码基因的多态性相关。
适应性左心室肥厚是运动员心脏的一个特征。然而，同样接受训练的运动员左心室质量增加的程度不同，这表明遗传因素可能会调节心脏大小。
我们通过超声心动图测量了50名男性和30名女性精英耐力运动员的左心室质量，这些运动员年龄为25±4（平均±标准差）岁。制备脱氧核糖核酸样本以对血管紧张素原（AGT）基因M235T多态性、血管紧张素转换酶（ACE）基因插入/缺失（I/D）多态性和血管紧张素II 1型受体（AT1）基因A1166C多态性进行基因分型。
AGT基因M235T基因型与左心室质量显著相关，且不受性别血压影响（合并数据p = 0.0036）。在男性（147±12 g/m² 对 132±15 g/m²，p = 0.032）和女性（121±12 g/m² 对 101±13 g/m²，p = 0.019）中，TT纯合子的左心室质量均高于MM纯合子。心肌质量与AGT基因型之间的关系存在性别差异，MT杂合子在女性中类似MM纯合子，在男性中类似TT纯合子。其他研究的基因多态性与左心室质量无关。
血管紧张素原基因M235T多态性与耐力训练诱导的左心室肥厚变异性相关，T等位基因纯合的运动员心脏最大。我们未发现ACE基因I/D或AT1基因A1166C多态性与左心室质量之间存在关联。
