血管紧张素原和血管紧张素转换酶基因多态性对心脏肥大的影响以及运动训练对最大有氧能力的改善作用。

Influence of angiotensinogen and angiotensin-converting enzyme polymorphisms on cardiac hypertrophy and improvement on maximal aerobic capacity caused by exercise training.

作者信息

Alves Guilherme B, Oliveira Edilamar M, Alves Cleber R, Rached Heron R S, Mota Glória F A, Pereira Alexandre C, Rondon Maria U, Hashimoto Nara Y, Azevedo Luciene F, Krieger José Eduardo, Negrão Carlos Eduardo

机构信息

Heart Institute (InCor), University of São Paulo, São Paulo, Brazil.

出版信息

Eur J Cardiovasc Prev Rehabil. 2009 Aug;16(4):487-92. doi: 10.1097/HJR.0b013e32832c5a8a.

DOI:10.1097/HJR.0b013e32832c5a8a

PMID:19404196

Abstract

BACKGROUND

The allele threonine (T) of the angiotensinogen has been associated with ventricular hypertrophy in hypertensive patients and soccer players. However, the long-term effect of physical exercise in healthy athletes carrying the T allele remains unknown. We investigated the influence of methionine (M) or T allele of the angiotensinogen and D or I allele of the angiotensin-converting enzyme on left-ventricular mass index (LVMI) and maximal aerobic capacity in young healthy individuals after long-term physical exercise training.

DESIGN

Prospective clinical trial.

METHODS

Eighty-three policemen aged between 20 and 35 years (mean+/-SD 26+/-4.5 years) were genotyped for the M235T gene angiotensinogen polymorphism (TT, n = 25; MM/MT, n = 58) and angiotensin-converting enzyme gene insertion/deletion (I/D) polymorphism (II, n = 18; DD/DI, n = 65). Left-ventricular morphology was evaluated by echocardiography and maximal aerobic capacity (VO2peak) by cardiopulmonary exercise test before and after 17 weeks of exercise training (50-80% VO2peak).

RESULTS

Baseline VO2peak and LVMI were similar between TT and MM/MT groups, and II and DD/DI groups. Exercise training increased significantly and similarly VO2peak in homozygous TT and MM/MT individuals, and homozygous II and DD/DI individuals. In addition, exercise training increased significantly LVMI in TT and MM/MT individuals (76.5+/-3 vs. 86.7+/-4, P = 0.00001 and 76.2+/-2 vs. 81.4+/-2, P = 0.00001, respectively), and II and DD/DI individuals (77.7+/-4 vs. 81.5+/-4, P = 0.0001 and 76+/-2 vs. 83.5+/-2, P = 0.0001, respectively). However, LVMI in TT individuals was significantly greater than in MM/MT individuals (P = 0.04). LVMI was not different between II and DD/DI individuals.

CONCLUSION

Left-ventricular hypertrophy caused by exercise training is exacerbated in homozygous TT individuals with angiotensinogen polymorphism.

摘要

背景

血管紧张素原的苏氨酸（T）等位基因与高血压患者及足球运动员的心室肥厚有关。然而，对于携带T等位基因的健康运动员进行体育锻炼的长期影响仍不清楚。我们研究了血管紧张素原的甲硫氨酸（M）或T等位基因以及血管紧张素转换酶的D或I等位基因对年轻健康个体长期体育锻炼训练后左心室质量指数（LVMI）和最大有氧能力的影响。

设计

前瞻性临床试验。

方法

对83名年龄在20至35岁之间（平均±标准差26±4.5岁）的警察进行血管紧张素原M235T基因多态性（TT，n = 25；MM/MT，n = 58）和血管紧张素转换酶基因插入/缺失（I/D）多态性（II，n = 18；DD/DI，n = 65）的基因分型。在17周的运动训练（50 - 80%最大摄氧量峰值）前后，通过超声心动图评估左心室形态，通过心肺运动试验评估最大有氧能力（VO2peak）。

结果

TT组与MM/MT组之间，以及II组与DD/DI组之间，基线VO2peak和LVMI相似。运动训练使纯合子TT和MM/MT个体以及纯合子II和DD/DI个体的VO2peak显著且相似地增加。此外,运动训练使TT和MM/MT个体的LVMI显著增加（分别为76.5±3对86.7±4，P = 0.00001和76.2±2对81.4±,2，P = 0.00001），以及II和DD/DI个体的LVMI显著增加（分别为77.7±4对81.5±4，P = 0.0001和76±2对83.5±2，P = 0.0001）。然而，TT个体的LVMI显著大于MM/MT个体（P = 0.04）。II和DD/DI个体之间的LVMI没有差异。