压力与免疫：对病毒性疾病和伤口愈合的影响。

Stress and immunity: implications for viral disease and wound healing.

作者信息

Rozlog L A, Kiecolt-Glaser J K, Marucha P T, Sheridan J F, Glaser R

机构信息

Department of Medical Microbiology and Immunology, College of Medicine, The Ohio State University, Columbus 43210, USA.

出版信息

J Periodontol. 1999 Jul;70(7):786-92. doi: 10.1902/jop.1999.70.7.786.

DOI:10.1902/jop.1999.70.7.786

PMID:10440641

Abstract

It is now well established that psychological stress can downregulate the cellular immune response. Communication between the central nervous system and the immune system occurs via a complex network of bidirectional signals linking the nervous, endocrine, and immune systems. Stress disrupts the homeostasis of this network, which in turn, alters immune function. In this review, we discuss the role of stress in modulating cellular immune function and the potential health implications of this downregulation.

摘要

现在已经充分证实，心理压力会下调细胞免疫反应。中枢神经系统和免疫系统之间通过连接神经、内分泌和免疫系统的复杂双向信号网络进行通信。压力会破坏这个网络的稳态，进而改变免疫功能。在这篇综述中，我们讨论了压力在调节细胞免疫功能中的作用以及这种下调对健康的潜在影响。