热休克蛋白90（Hsp90）是进化能力的调节因子吗？

Is Hsp90 a regulator of evolvability?

作者信息

Wagner G P, Chiu C H, Hansen T F

机构信息

Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520-8106, USA.

出版信息

J Exp Zool. 1999 Aug 15;285(2):116-8. doi: 10.1002/(sici)1097-010x(19990815)285:2<116::aid-jez3>3.0.co;2-p.

DOI:10.1002/(sici)1097-010x(19990815)285:2<116::aid-jez3>3.0.co;2-p

PMID:10440722

Abstract

In a recent paper, Rutherford and Lindquist (1998. Nature 396:336-342) identified mutations in the Hsp90 protein that act to unmask hidden genetic variation with a variety of phenotypic effects. The Hsp90 protein has a number of properties that suggest a role in regulating the expression of genetic variation and therefore in adjusting the evolvability of the organism. In this paper we reflect upon the evolutionary feasibility of such mechanisms and suggest some possible ways of testing the adaptation-for-evolvability hypothesis in more detail. We conclude that Hsp90 holds promise as a molecular model system for the evolution of evolvability. J. Exp. Zool. ( Mol. Dev. Evol. ) 285:116-118, 1999.

摘要

在最近的一篇论文中，卢瑟福和林德奎斯特（1998年，《自然》杂志396卷：336 - 342页）鉴定出热休克蛋白90（Hsp90）中的突变，这些突变会揭示出具有多种表型效应的隐藏遗传变异。热休克蛋白90具有多种特性，表明它在调节遗传变异的表达中发挥作用，因此也在调整生物体的进化能力方面发挥作用。在本文中，我们思考了这种机制在进化上的可行性，并提出了一些更详细地检验适应性进化能力假说的可能方法。我们得出结论，热休克蛋白90有望成为进化能力进化的分子模型系统。《实验动物学杂志》（分子与发育进化）285卷：116 - 118页，1999年。