热休克蛋白90（HSP90）在进化中的作用。

The role of HSP90 in evolution.

作者信息

Yahara I

机构信息

The Tokyo Metropolitan Institute of Medical Science, Honkomagome 3-18-22, Bunkyo-ku, Tokyo 113-8613, Japan.

出版信息

Genes Cells. 1999 Jul;4(7):375-9. doi: 10.1046/j.1365-2443.1999.00271.x.

DOI:10.1046/j.1365-2443.1999.00271.x

PMID:10469170

Abstract

A mechanism by which morphological mutations are stored without expressing phenotypes was unraveled by Rutherford & Lindquist (1998) through genetic studies of Hsp83 (HSP90) in Drosophila. Cryptic mutations are essentially neutral and therefore evolve in the absence of selective constraint. A shift from neutral mutations to selective mutations is induced when flies are exposed to environmental stress. This is a step toward understanding macroevolution in molecular terms.

摘要

卢瑟福和林德奎斯特（1998年）通过对果蝇中热休克蛋白83（HSP90）的遗传学研究，揭示了一种形态突变在不表达表型的情况下得以储存的机制。隐秘突变本质上是中性的，因此在没有选择限制的情况下进化。当果蝇暴露于环境压力时，会诱导从中性突变向选择性突变的转变。这是朝着从分子层面理解宏观进化迈出的一步。