Wagner A, Stadler P F
Department of Biology, University of New Mexico, Albuquerque, New Mexico 87131-1091, USA.
J Exp Zool. 1999 Aug 15;285(2):119-27.
Many properties of organisms show great robustness against mutations. Whether this robustness is an evolved property or intrinsic to genetic systems is by and large unknown. An evolutionary origin of robustness would require a rethinking of key concepts in the field of molecular evolution, such as gene-specific neutral mutation rates, or the context-independence of deleterious mutations. We provide evidence that mutational robustness of the genome of RNA viruses to mutational changes in secondary structure has evolved. J. Exp. Zool. ( Mol. Dev. Evol.) 285:119-127, 1999.
生物体的许多特性对突变具有很强的稳健性。这种稳健性是一种进化而来的特性还是遗传系统所固有的，目前大体上还不清楚。稳健性的进化起源将需要重新思考分子进化领域的关键概念，比如基因特异性中性突变率，或者有害突变的背景独立性。我们提供的证据表明，RNA病毒基因组对二级结构突变变化的突变稳健性是进化而来的。《实验动物学杂志》（分子发育与进化）285:119 - 127，1999年。
