Obler R, Köstler H, Weber B P, Mack K F, Becker H
Medizinische Hochschule Hannover, Abteilung Neuroradiologie, Zentrum Radiologie, Hannover, Germany.
Magn Reson Med. 1999 Aug;42(2):371-8. doi: 10.1002/(sici)1522-2594(199908)42:2<371::aid-mrm19>3.0.co;2-3.
The purpose of this study was to evaluate possibilities and technical risks for combining intended electrical stimulation of the cochlear nerve and functional magnetic resonance imaging (fMRI). Theoretical considerations and experiments indicate that fMRI can be performed safely during electrical stimulation. A nerve stimulator was developed with minimized length of electrical conductors, current limiting resistance, high inner impedance of a current source, radio frequency (RF)-shielding, and avoidance of ferromagnetic materials. This nerve stimulator transfers the optically encoded stimulating current signal via a fiber optic cable located near the area of stimulation. There, the optical signal drives an MRI-compatible current source. This set-up was tested with transtympanic electrical stimulation of the cochlear nerve at the promontory during an fMRI examination. No hazardous effects could be detected. The stimulation resulted in activation of the Heschl's gyrus. Compared to the conventional promontory testing this method may allow a more objective examination of cochlear implant candidates. Magn Reson Med 42:371-378, 1999.
本研究的目的是评估联合耳蜗神经电刺激与功能磁共振成像（fMRI）的可能性及技术风险。理论思考和实验表明，在电刺激期间可以安全地进行fMRI。开发了一种神经刺激器，其电导体长度最小化、具有限流电阻、电流源的内部阻抗高、有射频（RF）屏蔽且避免使用铁磁材料。该神经刺激器通过位于刺激区域附近的光纤电缆传输光学编码的刺激电流信号。在那里，光信号驱动一个与MRI兼容的电流源。在fMRI检查期间，通过在岬部对耳蜗神经进行经鼓膜电刺激来测试这种设置。未检测到有害影响。刺激导致了颞横回的激活。与传统的岬部测试相比，这种方法可能允许对人工耳蜗候选者进行更客观的检查。《磁共振医学》42:371 - 378, 1999。
