“Scraggly”，小鼠19号染色体上一种新的脱发突变。

Scraggly, a new hair loss mutation on mouse chromosome 19.

作者信息

Herron B J, Bryda E C, Heverly S A, Collins D N, Flaherty L

机构信息

Molecular Genetics Program, Laboratory of Developmental Genetics, Wadsworth Center, 120 New Scotland Avenue, P.O. Box 22002, Albany, New York 12201-2002, USA.

出版信息

Mamm Genome. 1999 Sep;10(9):864-9. doi: 10.1007/s003359901105.

DOI:10.1007/s003359901105

PMID:10441736

Abstract

By use of chlorambucil, we have generated a mouse mutation called scraggly (sgl) that exhibits skin and hair defects. Homozygous mutant mice exhibit hair loss, skin defects, and abnormalities in sebaceous lipid composition. We have constructed a high-resolution genetic map of mouse Chromosome (Chr) 19 that links this mutation to the anonymous DNA marker D19Umi1. An additional cross, (BALB/c x CAST/Ei) F(1) x BALB/c, was used to map markers around this mutation as well as to map the potential candidate genes, Fgf8 and Cyp17. Allelism tests between sgl and asebia (ab), another hair loss mutation on mouse Chr 19, showed that these genes were separate and distinct.

摘要

通过使用苯丁酸氮芥，我们培育出了一种名为“参差不齐”（sgl）的小鼠突变体，它表现出皮肤和毛发缺陷。纯合突变小鼠表现出脱发、皮肤缺陷以及皮脂腺脂质成分异常。我们构建了小鼠第19号染色体（Chr）的高分辨率遗传图谱，将该突变与匿名DNA标记D19Umi1联系起来。另外进行了一个杂交实验，即（BALB/c×CAST/Ei）F(1)×BALB/c，用于绘制该突变周围的标记以及潜在的候选基因Fgf8和Cyp17。对sgl与小鼠第19号染色体上另一个脱发突变“无皮脂”（ab）进行等位性测试，结果表明这些基因是独立且不同的。