Leonard H L, Swedo S E, Garvey M, Beer D, Perlmutter S, Lougee L, Karitani M, Dubbert B
Division of Child and Adolescent Psychiatry, Rhode Island Hospital, Providence, USA.
Child Adolesc Psychiatr Clin N Am. 1999 Jul;8(3):497-511.
The search for subtypes of OCD has led to increased appreciation of the importance of distinguishing early (prepubertal) versus later on-set, and of tic-related versus non-tic related subtypes, as well as postinfectious forms of the disorder. How these apparent typologies relate to each other remains to be elucidated. Careful longitudinal clinical descriptive studies, as well as the ongoing application of genetic, neuroimaging, and immunologic techniques, promise to advance our understanding of how genotype and environmental factors interact to produce the diverse clinical forms of OCD and to point the way to more effective treatment.
对强迫症亚型的研究使人们更加认识到区分早期（青春期前）发病与后期发病、抽动相关亚型与非抽动相关亚型以及该疾病感染后形式的重要性。这些明显的类型学之间的关系仍有待阐明。细致的纵向临床描述性研究，以及基因、神经影像学和免疫学技术的不断应用，有望增进我们对基因型和环境因素如何相互作用以产生强迫症的多种临床形式的理解，并为更有效的治疗指明方向。
