Miyazato M, Koyama Y, Miyazato T, Kagawa H, Yonou H, Sugaya K, Hatano T, Ogawa Y
Department of Urology, Faculty of Medicine, University of the Ryukyus.
Hinyokika Kiyo. 1999 Jun;45(6):427-9.
Renal transplantation for patients with systemic lupus erythematosus (SLE) remains controversial. We performed living-tissue related renal transplantation on a 45-year-old woman with SLE and an eight-month history of hemodialysis. We also did cadaveric renal transplantation on a 41-year-old man with SLE and a 12-year history of hemodialysis. Serological tests including tests for antinuclear antibodies and complements were negative prior to surgery and throughout the course in both cases. The latter patients survived herpes-zoster virus infection in month 6 and bacterial pneumonia in month 9 after transplantation. Neither patient experienced any rejection or relapse of lupus nephritis after the procedure, and both maintained good renal allograft functions. The recurrence of lupus nephritis is reportedly extremely rare, i.e., with a possibility rate of less than 1% in transplant patients with burnt-out SLE. To the best of our knowledge, these cases are the 27th and 28th case reports of renal transplantation for SLE patients in Japanese literature.
系统性红斑狼疮（SLE）患者的肾移植仍存在争议。我们对一名45岁、有8个月血液透析史的SLE女性患者进行了活体组织相关肾移植。我们还对一名41岁、有12年血液透析史的SLE男性患者进行了尸体肾移植。在两例患者中，术前及整个病程中的血清学检查，包括抗核抗体和补体检测均为阴性。后一名患者在移植后第6个月发生带状疱疹病毒感染，第9个月发生细菌性肺炎。术后两名患者均未出现任何排斥反应或狼疮性肾炎复发，且移植肾功能均保持良好。据报道，狼疮性肾炎的复发极为罕见，即在狼疮病情静止的移植患者中复发率不到1%。据我们所知，这些病例是日本文献中第27和28例SLE患者肾移植的病例报告。
