Mejia G, Zimmerman S W, Glass N R, Miller D T, Sollinger H W, Belzer F O
Arch Intern Med. 1983 Nov;143(11):2089-92.
The activity of systemic lupus erythematosus (SLE) was investigated in 18 recipients of 20 renal transplants by retrospective analysis of their medical records and by screening the ten patients with more than one year follow-up. Eight grafts were lost, all because of rejection occurring within the first year. From the 12 patients with functioning transplants, one was lost to follow-up at seven years and another had not completed one year. The remaining ten patients were studied, and no evidence of lupus nephritis was found despite serologically active SLE in four cases. Their follow-up was 4.5 +/- 1.3 years. Our study provides the relatively scarce literature on renal transplantation in patients with SLE with a series of 18 recipients of 20 allografts, confirms that the recurrence of lupus nephritis in the allografts is very rare, as previously suggested, and discloses that graft and patient survivals are comparable with those of the general nondiabetic transplant population.
通过回顾性分析病历并对10例随访超过一年的患者进行筛查，对20例肾移植的18例受者的系统性红斑狼疮（SLE）活动情况进行了研究。8个移植物失功，均因第一年发生排斥反应。在12例移植肾功能正常的患者中，1例在7年时失访，另1例未完成一年随访。对其余10例患者进行了研究，尽管4例患者血清学检查显示SLE活动，但未发现狼疮性肾炎的证据。他们的随访时间为4.5±1.3年。我们的研究提供了相对稀少的关于SLE患者肾移植的文献，涉及20例同种异体移植的18例受者，证实了如先前所述，同种异体移植中狼疮性肾炎的复发非常罕见，并表明移植物和患者的存活率与一般非糖尿病移植人群相当。
