甲型血友病伴抑制剂患者的脊柱硬膜外血肿——重组凝血因子VIIa浓缩剂的疗效

Spinal epidural haematoma in haemophilia A with inhibitors--efficacy of recombinant factor VIIa concentrate.

作者信息

Leach M, Makris M, Hampton K K, Preston F E

机构信息

Department of Haematology, Royal Hallamshire Hospital, Sheffield, UK.

出版信息

Haemophilia. 1999 May;5(3):209-12. doi: 10.1046/j.1365-2516.1999.00301.x.

DOI:10.1046/j.1365-2516.1999.00301.x

PMID:10444290

Abstract

We report the case of a 21-year-old man with severe haemophilia A and factor VIII inhibitors who presented with an extensive spinal epidural haematoma (C2-T12), probably induced by sit-up exercises. The bleed was defined by magnetic resonance imaging of the cervical and thoracic spine and prompt treatment with recombinant factor VIIa concentrate led to complete resolution at 4 weeks. Neurological sequelae were averted and surgical decompression was not necessary. We discuss the difficulties in diagnosis and management of such a case.

摘要

我们报告了一例21岁患有严重甲型血友病且伴有凝血因子VIII抑制物的男性病例，该患者因仰卧起坐运动引发广泛的脊柱硬膜外血肿（C2 - T12）。颈椎和胸椎的磁共振成像明确了出血情况，重组凝血因子VIIa浓缩剂的及时治疗使血肿在4周时完全消退。避免了神经后遗症，无需进行手术减压。我们讨论了此类病例在诊断和管理方面的困难。