Cantile C, Baroni M, Arispici M
Dipartimento di Patologia Animale, Facoltà di Medicina Veterinaria, Università di Pisa, Italy.
Zentralbl Veterinarmed A. 1999 Jul;46(5):301-8. doi: 10.1046/j.1439-0442.1999.00219.x.
Narcolepsy associated with localized brain lesions is described in a 10-month-old Argentine Dogo. Neurological examination and MRI study suggested an inflammatory lesion of the left frontal lobe. Postmortem examination revealed diffuse encephalitis in the forebrain and marked necrotic lesions in the ventral pontine area. Immunohistochemistry for distemper virus antigen showed positive staining of the cytoplasm of many neurones of the pons and cerebral cortex. The pathological pattern was suggestive of post-vaccinal distemper encephalitis and the localization of the lesions was consistent with the neurological syndrome shown by the animal. At any event, the possibility of coincidental findings of distemper encephalitis and idiopathic narcolepsy must be accounted for.
一只10个月大的阿根廷杜高犬被描述患有与局限性脑损伤相关的发作性睡病。神经学检查和磁共振成像研究表明左侧额叶有炎症性损伤。尸检显示前脑弥漫性脑炎，脑桥腹侧区域有明显坏死性病变。犬瘟热病毒抗原免疫组化显示脑桥和大脑皮质许多神经元的细胞质呈阳性染色。病理模式提示疫苗接种后犬瘟热脑炎，病变定位与该动物所表现的神经综合征一致。无论如何，必须考虑犬瘟热脑炎和特发性发作性睡病巧合发现的可能性。
