Brunetto M R, Alarcón O M, Dávila E, Contreras Y, Gallignani M, Rondón C, Burguera J L, Burguera M, Angarita C
IVAIQUIM (Venezuelan Andean Institute for Chemical Research), Faculty of Sciences, University of Los Andes, Mérida, Venezuela.
J Trace Elem Med Biol. 1999 Jul;13(1-2):40-50. doi: 10.1016/S0946-672X(99)80022-4.
Zn (SZn), Cu (SCu), Fe (SFe), vitamin A (SVA) and vitamin E (SVE) were measured in blood serum samples of 85 healthy pre-school children aged 2-6 yr. from the rural community of Canaguá, Mérida State, Venezuela. The relationship between these biochemical indexes was also investigated. The mean serum concentrations of zinc, copper, iron, vitamin A and vitamin E were 0.74 +/- 0.25, 1.18 +/- 0.30, 0.76 +/- 0.20, 0.30 +/- 0.15 and 5.87 +/- 0.43 mg/L, respectively. There was a tendency for SZn to increase with age, whereas SCu and SVA decreased. There was no significant difference in serum trace elements and fat-soluble vitamin concentration between males and females in the different age groups. SFe tended to be lower than that reported in the literature. However, the age groups studied showed no statistically significant sex- and age-related differences. The present study shows that there is a complex interaction between SZn, SCu, SFe, SVA, SVE and age of the children. Multiple regression analysis showed serum zinc was strongly related to serum copper, and serum iron. Serum vitamin A was strongly related to serum zinc and serum vitamin E, whereas serum vitamin E was strongly related to serum zinc, serum copper, and serum vitamin A. On the other hand, our observations also suggest that more detailed studies of these metals and fat-soluble vitamins should be carried out, and that the study should include nutritional surveys, metabolic balances and associations between SZn, SCu, SFe, SVA and SVE and anthropometric variables (height, weight, body mass index and skinfold thickness).
对来自委内瑞拉梅里达州卡纳瓜农村社区的85名2至6岁健康学龄前儿童的血清样本进行了锌（SZn）、铜（SCu）、铁（SFe）、维生素A（SVA）和维生素E（SVE）的测定。还研究了这些生化指标之间的关系。锌、铜、铁、维生素A和维生素E的血清平均浓度分别为0.74±0.25、1.18±0.30、0.76±0.20、0.30±0.15和5.87±0.43mg/L。SZn有随年龄增加的趋势，而SCu和SVA则下降。不同年龄组的男性和女性血清微量元素和脂溶性维生素浓度没有显著差异。SFe往往低于文献报道的值。然而，所研究的年龄组在性别和年龄方面没有统计学上的显著差异。本研究表明，SZn、SCu、SFe、SVA、SVE与儿童年龄之间存在复杂的相互作用。多元回归分析表明，血清锌与血清铜和血清铁密切相关。血清维生素A与血清锌和血清维生素E密切相关，而血清维生素E与血清锌、血清铜和血清维生素A密切相关。另一方面，我们的观察结果还表明，应该对这些金属和脂溶性维生素进行更详细的研究，并且该研究应包括营养调查、代谢平衡以及SZn、SCu、SFe、SVA和SVE与人体测量变量（身高、体重、体重指数和皮褶厚度）之间的关联。
