Gupta M C, Garg S K
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Methods Find Exp Clin Pharmacol. 1999 Jul-Aug;21(6):453-5. doi: 10.1358/mf.1999.21.6.541928.
Nimodipine, a dihydropyridine calcium channel blocker, has been shown to cause a potentiation of anticonvulsant action of phenytoin (DPH) against maximal electroshock-induced seizures in rats. This crossover study was carried out in rhesus monkeys to determine if any pharmacokinetic interaction was involved in such a potentiation. The steady state pharmacokinetics of phenytoin was examined before and after nimodipine administration. No significant differences were observed in plasma concentration of phenytoin at different time points nor in any of the pharmacokinetic parameters in the two groups. The results reveal that the potentiation of anticonvulsant action of phenytoin by nimodipine is probably due to a pharmacodynamic interaction between the two drugs.
尼莫地平是一种二氢吡啶类钙通道阻滞剂，已被证明可增强苯妥英（DPH）对大鼠最大电休克诱发惊厥的抗惊厥作用。本交叉研究在恒河猴中进行，以确定这种增强作用是否涉及任何药代动力学相互作用。在给予尼莫地平之前和之后，对苯妥英的稳态药代动力学进行了检查。两组在不同时间点的苯妥英血浆浓度以及任何药代动力学参数均未观察到显著差异。结果表明，尼莫地平对苯妥英抗惊厥作用的增强可能是由于两种药物之间的药效学相互作用。
