尼莫地平及两种新型二氢吡啶类化合物（PCA 50922和PCA 50941）对小鼠戊四氮诱发惊厥和电惊厥休克的抗惊厥作用。
Anticonvulsant effects of nimodipine and two novel dihydropyridines (PCA 50922 and PCA 50941) against seizures elicited by pentylenetetrazole and electroconvulsive shock in mice.
作者信息
Zapater P, Javaloy J, Román J F, Vidal M T, Horga J F
机构信息
Department of Pharmacology and Therapeutics, Faculty of Medicine, Universidad Autónoma de Madrid, Spain.
出版信息
Brain Res. 1998 Jun 15;796(1-2):311-4. doi: 10.1016/s0006-8993(98)00352-7.
In animal models of epilepsy, calcium entry blockers have shown anticonvulsant properties. We studied the antiepileptic effects of nimodipine and two novel dihydropyridines, a calcium antagonist (PCA 50922) and a calcium agonist (PCA 50941), on pentylenetetrazole seizure and maximal electroshock seizure (MES) in mice. Anticonvulsant profile of nimodipine and PCA 50922 was similar to that of clonazepam, but markedly different from that of phenytoin. None of the doses of the PCA 50941 showed anticonvulsant effect.
在癫痫动物模型中，钙通道阻滞剂已显示出抗惊厥特性。我们研究了尼莫地平以及两种新型二氢吡啶类药物（一种钙拮抗剂PCA 50922和一种钙激动剂PCA 50941）对小鼠戊四氮惊厥和最大电休克惊厥（MES）的抗癫痫作用。尼莫地平和PCA 50922的抗惊厥谱与氯硝西泮相似，但与苯妥英明显不同。PCA 50941的任何剂量均未显示出抗惊厥作用。
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