Ahlers C, Hüttner K, Pfeiffer D
Basic Animal Health Service Project/GTZ, Mzuzu, Malawi.
Trop Anim Health Prod. 1999 Jun;31(3):167-74. doi: 10.1023/a:1005117613340.
A total of 156 chickens in two villages in Malawi were marked and sampled. One hundred and fifteen of these were vaccinated against Newcastle disease immediately after blood sampling, using the V4 heat-resistant strain applied by eye-drop in one village and the inactivated Newcavac vaccine in the other village. A second blood sample was collected 4 weeks after vaccination. The samples were examined using an indirect ELISA test kit. The titre group median ranged from 2 to 3 before vaccination. Both vaccines led to a positive immune response. Newcavac induced higher and more homogeneous titres compared with the V4 vaccine. There was also an increase in the median of the control group where V4 live vaccine had been applied. The differences between the median titres induced by V4, Newcavac and controls were statistically significant.
在马拉维的两个村庄，共对156只鸡进行了标记和采样。其中115只在采血后立即接种了新城疫疫苗，一个村庄采用V4耐热株通过滴眼方式接种，另一个村庄则使用灭活的Newcavac疫苗。接种疫苗4周后采集第二份血样。使用间接ELISA检测试剂盒对样本进行检测。接种疫苗前，滴度组中位数在2至3之间。两种疫苗均引发了阳性免疫反应。与V4疫苗相比，Newcavac诱导的滴度更高且更均匀。在应用V4活疫苗的对照组中，中位数也有所增加。V4、Newcavac和对照组诱导的中位数滴度之间的差异具有统计学意义。
