Giancotti F G, Ruoslahti E
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Science. 1999 Aug 13;285(5430):1028-32. doi: 10.1126/science.285.5430.1028.
Cells reside in a protein network, the extracellular matrix (ECM), which they secrete and mold into the intercellular space. The ECM exerts profound control over cells. The effects of the matrix are primarily mediated by integrins, a family of cell surface receptors that attach cells to the matrix and mediate mechanical and chemical signals from it. These signals regulate the activities of cytoplasmic kinases, growth factor receptors, and ion channels and control the organization of the intracellular actin cytoskeleton. Many integrin signals converge on cell cycle regulation, directing cells to live or die, to proliferate, or to exit the cell cycle and differentiate.
细胞存在于一个蛋白质网络——细胞外基质（ECM）中，该基质由细胞分泌并塑造到细胞间空间。细胞外基质对细胞具有深远的控制作用。基质的作用主要由整合素介导，整合素是一类细胞表面受体家族，它将细胞附着于基质并介导来自基质的机械和化学信号。这些信号调节细胞质激酶、生长因子受体和离子通道的活性，并控制细胞内肌动蛋白细胞骨架的组织。许多整合素信号汇聚于细胞周期调控，引导细胞生存或死亡、增殖，或退出细胞周期并分化。
