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2
Gastric microcirculatory changes during gastric tube formation: assessment with laser Doppler flowmetry.胃管形成过程中的胃微循环变化：激光多普勒血流仪评估
J Surg Res. 1996 Apr;62(1):125-9. doi: 10.1006/jsre.1996.0184.
3
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Ann Surg. 1995 Dec;222(6):695-9. doi: 10.1097/00000658-199512000-00002.
4
PECAM-1 (CD31) is expressed on proliferating endothelial cells, stromal spindle-shaped cells, and dermal dendrocytes in Kaposi's sarcoma.血小板内皮细胞黏附分子-1（CD31）在卡波西肉瘤中增殖的内皮细胞、基质梭形细胞和真皮树突状细胞上表达。
Arch Dermatol. 1993 Feb;129(2):250-1.
5
Observer agreement and variability in measuring gastric mucosal blood flow by laser Doppler flowmetry in humans.人体激光多普勒血流仪测量胃黏膜血流的观察者一致性及变异性
Endoscopy. 1993 May;25(4):274-7. doi: 10.1055/s-2007-1010313.
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Gastroenterology. 1993 Dec;105(6):1846-56. doi: 10.1016/0016-5085(93)91084-u.
7
Prostaglandins and gangliosides of tumor microenvironment: their role in angiogenesis.肿瘤微环境中的前列腺素和神经节苷脂：它们在血管生成中的作用。
Acta Oncol. 1995;34(3):439-41. doi: 10.3109/02841869509094005.
8
Tumor cells secrete an angiogenic factor that stimulates basic fibroblast growth factor and urokinase expression in vascular endothelial cells.肿瘤细胞分泌一种血管生成因子，该因子可刺激血管内皮细胞中的碱性成纤维细胞生长因子和尿激酶的表达。
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Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis.与血管生成相关的肾细胞癌中，血管内皮生长因子和胎盘生长因子的信使核糖核酸量显著增加。
Cancer Res. 1994 Aug 1;54(15):4233-7.
10
The observation of angiogenin and basic fibroblast growth factor gene expression in human colonic adenocarcinomas, gastric adenocarcinomas, and hepatocellular carcinomas.人结肠腺癌、胃腺癌和肝细胞癌中血管生成素及碱性成纤维细胞生长因子基因表达的观察
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激光多普勒血流仪用于体内研究良性和恶性胃血流的评估。

Evaluation of laser doppler flowmetry for the study of benign and malignant gastric blood flow in vivo.

作者信息

Schilling M K, Redaelli C, Friess H, Blum B, Signer C, Maurer C A, Büchler M W

机构信息

Department of Visceral and Transplant Surgery, University of Bern, Inselspital, Bern, Switzerland.

出版信息

Gut. 1999 Sep;45(3):341-5. doi: 10.1136/gut.45.3.341.

DOI:10.1136/gut.45.3.341
PMID:10446100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1727638/
Abstract

BACKGROUND

Tumour vascularisation is a determinant of the development of metastases.

AIMS

To measure blood flow in normal stomach and gastric adenocarcinomas by laser Doppler flowmetry and correlate blood flow with vascularisation after immunohistochemical staining of resected specimens for CD31 and von Willebrand factor.

PATIENTS

Twenty two undergoing resection for gastric adenocarcinoma and 10 undergoing cholecystectomy.

RESULTS

Mean (SD) gastric blood flow was 208 (35) perfusion units (PU) in patients undergoing cholecystectomy and 190 (75) PU in the undiseased part of the stomach in patients with gastric adenocarcinoma. Gastric blood flow was higher in the border of gastric adenocarcinomas (322 (120) PU, p<0.01 v normal stomach) but lower in the centre (74 (27) PU, p<0.01 v normal stomach and tumour border). Blood flow was higher in tumours staged T>/=3 than in those staged T<3. Blood vessel density in normal stomach was 41 (8) stained cells/field viewed and was 1. 9-3.4 times higher in gastric adenocarcinomas.

CONCLUSION

Laser Doppler flowmetry is a valuable tool for studying the pathophysiological alterations of malignant blood flow in the human stomach in vivo.

摘要

背景

肿瘤血管形成是转移发生的一个决定因素。

目的

通过激光多普勒血流仪测量正常胃组织和胃腺癌组织中的血流，并在对切除标本进行CD31和血管性血友病因子免疫组化染色后，将血流与血管形成情况进行关联分析。

患者

22例行胃腺癌切除术的患者和10例行胆囊切除术的患者。

结果

行胆囊切除术患者的平均（标准差）胃血流量为208（35）灌注单位（PU），胃腺癌患者未患病胃组织部分的平均胃血流量为190（75）PU。胃腺癌边界处的胃血流量较高（322（120）PU，与正常胃组织相比p<0.01），但中心处较低（74（27）PU，与正常胃组织和肿瘤边界相比p<0.01）。T≥3期肿瘤的血流量高于T<3期肿瘤。正常胃组织的血管密度为41（8）个染色细胞/视野，胃腺癌的血管密度比正常胃组织高1.9 - 3.4倍。

结论

激光多普勒血流仪是在体研究人胃恶性血流病理生理改变的一种有价值的工具。