大鼠视交叉上核中1型和3型肌醇三磷酸受体的差异表达模式
Differential expression patterns of inositol trisphosphate receptor types 1 and 3 in the rat suprachiasmatic nucleus.
作者信息
Hamada T, Niki T, Ziging P, Sugiyama T, Watanabe S, Mikoshiba K, Ishida N
机构信息
Ishida Group of Clock Gene, National Institute of Bioscience and Human Technology, AIST, MITI, 1-1 Higashi, Tsukuba Science City 305-8566, Japan.
出版信息
Brain Res. 1999 Aug 14;838(1-2):131-5. doi: 10.1016/s0006-8993(99)01719-9.
Inositol 1,4,5-trisphosphate receptor types 1 (IP(3)-R1) and 3 (IP(3)-R3) were found in the rat suprachiasmatic nucleus (SCN) and the levels of both of IP(3)-R1 and IP(3)-R3 mRNA showed a reciprocal circadian rhythm. IP(3)-R1 immunoreactive cells were localized in neuronal cells in the SCN. In contrast, IP(3)-R3 immunoreactive cells were mainly localized in the astrocytes in the ventrolateral region of the SCN. These results suggest that IP(3)-R1 and IP(3)-R3 may have differential roles in the SCN in the mammalian circadian rhythm.
在大鼠视交叉上核（SCN）中发现了1,4,5-三磷酸肌醇受体1型（IP(3)-R1）和3型（IP(3)-R3），且IP(3)-R1和IP(3)-R3 mRNA的水平呈现出相反的昼夜节律。IP(3)-R1免疫反应性细胞定位于SCN的神经元细胞中。相比之下，IP(3)-R3免疫反应性细胞主要定位于SCN腹外侧区域的星形胶质细胞中。这些结果表明，IP(3)-R1和IP(3)-R3在哺乳动物昼夜节律的SCN中可能具有不同的作用。
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