Kitano K, Shimodaira S, Ito T, Ichikawa N, Kodaira H, Kohara Y, Ueno M, Tahara T, Kato T, Ishida F, Kiyosawa K
Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Int J Hematol. 1999 Jul;70(1):52-5.
Three patients with liver cirrhosis (LC) and a bleeding tendency due to marked thrombocytopenia of less than 20 x 10(9)/l were admitted to our hospital for further examination. Bone marrow examination revealed megakaryocytic hypoplasia in all three patients. All patients exhibited amegakaryocytic thrombocytopenic purpura, myelodysplastic syndrome, or bone marrow hypoplasia. 111In-labeled platelet kinetic studies revealed decreased platelet production in all patients. Although serum thrombopoietin (sTPO) levels are usually within the normal level in patients with LC, the sTPO levels of our patients were about 10 times higher than the levels of normal subjects (1.22 +/- 0.37 fmol/ml): 13.34, 16.79, and 10.46 fmol/ml, respectively. These sTPO data supported our findings of decreased megakaryopoiesis. Our findings suggest that examination of sTPO levels is useful in determining the etiology of marked thrombocytopenia in LC patients.
三名肝硬化（LC）患者因血小板显著减少（低于20×10⁹/L）且有出血倾向入住我院进一步检查。骨髓检查显示所有三名患者巨核细胞发育不全。所有患者均表现为无巨核细胞性血小板减少性紫癜、骨髓增生异常综合征或骨髓发育不全。¹¹¹In标记的血小板动力学研究显示所有患者血小板生成减少。虽然LC患者的血清血小板生成素（sTPO）水平通常在正常范围内，但我们患者的sTPO水平比正常受试者水平高约10倍（1.22±0.37 fmol/ml），分别为13.34、16.79和10.46 fmol/ml。这些sTPO数据支持了我们关于巨核细胞生成减少的发现。我们的发现表明，检测sTPO水平有助于确定LC患者显著血小板减少的病因。
