Meistrich M L, Wilson G, Huhtaniemi I
Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Cancer Res. 1999 Aug 1;59(15):3557-60.
Previous studies have shown that treatment of rats with gonadotropin-releasing hormone (GnRH) analogues or steroids either before exposure to procarbazine or radiation or after irradiation enhances subsequent levels of spermatogenesis. We demonstrate here that giving a GnRH agonist after procarbazine injection also enhances spermatogenesis and fertility. We also demonstrate that GnRH agonist stimulated recovery of spermatogenesis and fertility not only when the hormone was administered immediately after irradiation, but also at 20 weeks after irradiation, after the decline in spermatogenesis had occurred. These results suggest that GnRH agonist treatment given to azoospermic men after cytotoxic therapy for cancer may stimulate the recovery of spermatogenesis and fertility.
先前的研究表明，在大鼠接触丙卡巴肼或接受辐射之前或辐射之后，用促性腺激素释放激素（GnRH）类似物或类固醇进行处理可提高随后的精子发生水平。我们在此证明，在注射丙卡巴肼后给予GnRH激动剂也可提高精子发生水平和生育能力。我们还证明，GnRH激动剂不仅在辐射后立即给予时能刺激精子发生和生育能力的恢复，而且在辐射后20周，即精子发生出现下降之后给予时也能刺激其恢复。这些结果表明，对因癌症接受细胞毒性治疗后的无精子症男性给予GnRH激动剂治疗可能会刺激精子发生和生育能力的恢复。
