Smuts C M, Tichelaar H Y, Dhansay M A, Faber M, Smith J, Kirsten G F
National Research Programme for Nutritional Intervention, MRC, Tygerberg, South Africa.
Acta Paediatr. 1999 Jul;88(7):757-62. doi: 10.1080/08035259950169053.
This study investigated the effect of alcohol consumption and smoking during pregnancy on the fatty acid composition of the infants. A total of 40 very-low-birth-weight (VLBW) infants, weighing between 750 and 1500 g, were enrolled in the study after being hospitalized and ventilated for respiratory distress syndrome (RDS). Maternal and infant demographic information was recorded. Questions regarding maternal smoking (none, < 10 and > or = 10 cigarettes/d) and alcohol consumption (none, occasionally, moderate and severe) were recorded. Erythrocyte membrane (EMB; n = 40) total fatty acid analyses were performed at birth (baseline) and on days 14 and 28 postnatally. During pregnancy, 42% of mothers consumed alcohol and 50% smoked. At birth, infants of mothers who smoked and consumed alcohol during pregnancy, had significantly higher blood docosahexaenoic acid (DHA; p < 0.05) than infants of mothers who abstained from both alcohol and smoking. The consequences of this finding remain unknown.
本研究调查了孕期饮酒和吸烟对婴儿脂肪酸组成的影响。共有40名极低出生体重（VLBW）婴儿，体重在750至1500克之间，因呼吸窘迫综合征（RDS）住院并接受通气治疗后被纳入研究。记录了母婴的人口统计学信息。记录了有关母亲吸烟情况（不吸烟、每天<10支和≥10支）和饮酒情况（不饮酒、偶尔饮酒、中度饮酒和重度饮酒）的问题。在出生时（基线）以及出生后第14天和第28天对红细胞膜（EMB；n = 40）进行了总脂肪酸分析。孕期，42%的母亲饮酒，50%的母亲吸烟。出生时，孕期吸烟且饮酒的母亲所生婴儿的血液二十二碳六烯酸（DHA）含量显著高于不饮酒且不吸烟母亲所生婴儿（p < 0.05）。这一发现的后果尚不清楚。
