Smuts Cornelius M, Borod Emily, Peeples Jeanette M, Carlson Susan E
Medical Research Council, Tygerberg, South Africa.
Lipids. 2003 Apr;38(4):407-14. doi: 10.1007/s11745-003-1076-y.
Dietary DHA enhances infant attention and visual development. Because the DHA content of red blood cells and plasma lipids varies approximately threefold in pregnancy, maternal DHA status may influence subsequent infant function. It would be feasible to study the effects of higher maternal DHA intake on infant development if dietary intake of DHA could be increased by a reliable means. This study was designed to determine whether women provided with one dozen high-DHA hen eggs (135 mg DHA/egg) would consume the eggs and have higher blood DHA levels than women consuming ordinary eggs (18 mg DHA/egg). The study was a randomized, double-masked comparison of the effect of eggs with different concentrations of DHA on intake and blood lipid DHA content of women and their infants. A third nonrandomized group ate few eggs. In this study, DHA intake reported from eggs was eightfold higher in the high-DHA egg group compared to the ordinary egg group. Including all groups, DHA intake ranged from 0 to 284 mg/d. In this intake range, maternal blood lipid DHA content at enrollment best predicted DHA content at delivery, accounting for 36.5 and 51.7% of the variance in ordinary and high-DHA egg intake groups, respectively. The high-DHA vs. ordinary egg groups had similar maternal and cord blood lipid DHA, but there was a positive relationship between maternal plasma phospholipid DHA and daily DHA intake from eggs controlled for study duration (r = 0.278, P = 0.048). DHA intake and birth weight were also correlated (r = 0.299, P = 0.041). High-DHA eggs were well accepted and increased DHA intake. Other benefits of DHA intake during pregnancy were also suggested.
膳食中的二十二碳六烯酸（DHA）可促进婴儿注意力和视觉发育。由于孕期红细胞和血浆脂质中的DHA含量大约有三倍的差异，母亲的DHA状态可能会影响婴儿随后的功能。如果能够通过可靠的方法增加DHA的膳食摄入量，研究母亲摄入更多DHA对婴儿发育的影响将是可行的。本研究旨在确定食用一打高DHA含量鸡蛋（每个鸡蛋含135毫克DHA）的女性是否会食用这些鸡蛋，以及她们的血液DHA水平是否高于食用普通鸡蛋（每个鸡蛋含18毫克DHA）的女性。该研究是一项随机、双盲比较，比较不同DHA浓度的鸡蛋对女性及其婴儿的摄入量和血脂DHA含量的影响。第三个非随机组很少吃鸡蛋。在本研究中，高DHA鸡蛋组报告的来自鸡蛋的DHA摄入量比普通鸡蛋组高八倍。包括所有组在内，DHA摄入量范围为0至284毫克/天。在这个摄入量范围内，入组时母亲血脂DHA含量最能预测分娩时的DHA含量，分别占普通鸡蛋摄入组和高DHA鸡蛋摄入组差异的36.5%和51.7%。高DHA鸡蛋组与普通鸡蛋组的母亲和脐带血脂DHA相似，但在控制研究持续时间的情况下，母亲血浆磷脂DHA与每日从鸡蛋中摄入的DHA之间存在正相关关系（r = 0.278，P = 0.048）。DHA摄入量与出生体重也相关（r = 0.299，P = 0.041）。高DHA鸡蛋很受欢迎，并且增加了DHA摄入量。研究还表明了孕期摄入DHA的其他益处。
