Furuse M, Ao R, Bungo T, Ando R, Shimojo M, Masuda Y, Saito N
Laboratory of Animal Feed Science, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
Life Sci. 1999;65(3):305-11. doi: 10.1016/s0024-3205(99)00249-0.
The gastrin/cholecystokinin (CCK) family is recognized as the principal family of hormones involved in regulation of the gastrointestinal tract CCK is recognized as a satiety hormone in mammalian species, but it has been suggested that gastrin rather CCK may have an important role in controlling feeding behavior in the neonatal chick through a poorly developed blood brain barrier. So far, however, there is no direct evidence that central gastrin inhibits food intake in neonatal chicks. The aim of this study was to elucidate whether central administration of gastrin 1) inhibits feeding behavior and 2) alters food passage from the crop. The effects of central administration of gastrin on food intake were investigated in experiment 1. Birds (2-day-old) were food-deprived for 3 h and then gastrin or saline was injected intracerebroventricularly. Gastrin strongly inhibited food intake in a dose-dependent fashion for 2 h. Thereafter, the effects of central gastrin on feeding behavior and serum corticosterone concentration were examined in experiment 2. Following central administration of gastrin, food intake was depressed and pecking behavior was inhibited. Serum corticosterone concentration was not altered by central administration of gastrin. The influence of central gastrin on food passage from the crop was investigated in experiment 3. Central administration of gastrin clearly delayed food passage. In conclusion, central gastrin appears to have a strong effect for the satiety and gastrointestinal motility in the neonatal chick.
胃泌素/胆囊收缩素（CCK）家族被认为是参与胃肠道调节的主要激素家族。在哺乳动物中，CCK被认为是一种饱腹感激素，但有研究表明，由于新生雏鸡的血脑屏障发育不完善，胃泌素而非CCK可能在控制其摄食行为中发挥重要作用。然而，到目前为止，尚无直接证据表明中枢胃泌素能抑制新生雏鸡的食物摄入。本研究的目的是阐明中枢给予胃泌素是否：1）抑制摄食行为；2）改变嗉囊中的食物通过情况。实验1研究了中枢给予胃泌素对食物摄入的影响。将2日龄雏鸡禁食3小时，然后脑室内注射胃泌素或生理盐水。胃泌素以剂量依赖的方式强烈抑制食物摄入达2小时。此后，在实验2中检测了中枢胃泌素对摄食行为和血清皮质酮浓度的影响。中枢给予胃泌素后，食物摄入量减少，啄食行为受到抑制。中枢给予胃泌素未改变血清皮质酮浓度。实验3研究了中枢胃泌素对嗉囊中食物通过的影响。中枢给予胃泌素明显延迟了食物通过。总之，中枢胃泌素似乎对新生雏鸡的饱腹感和胃肠动力有很强的影响。
