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Ca2+ spark termination: inactivation and adaptation may be manifestations of the same mechanism.

作者信息

Györke S

出版信息

J Gen Physiol. 1999 Jul;114(1):163-6. doi: 10.1085/jgp.114.1.163.

DOI:10.1085/jgp.114.1.163
PMID:10447410
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2229634/
Abstract
摘要

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Markovian models of low and high activity levels of cardiac ryanodine receptors.心脏兰尼碱受体低活性和高活性水平的马尔可夫模型。
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Questions about adaptation in ryanodine receptors.
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Do inactivation mechanisms rather than adaptation hold the key to understanding ryanodine receptor channel gating?失活机制而非适应性才是理解兰尼碱受体通道门控的关键所在吗？
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本文引用的文献

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Response.反应
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Modal gating transitions in cardiac ryanodine receptors during increases of Ca2+ concentration produced by photolysis of caged Ca2+.在通过光解笼锁Ca2+产生的Ca2+浓度增加过程中，心脏雷诺丁受体的模态门控转换。
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Termination of Ca2+ release by a local inactivation of ryanodine receptors in cardiac myocytes.心肌细胞中兰尼碱受体局部失活导致钙离子释放终止。
Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):15096-101. doi: 10.1073/pnas.95.25.15096.
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Regulation of the cardiac ryanodine receptor channel by luminal Ca2+ involves luminal Ca2+ sensing sites.肌浆网腔Ca2+对心肌兰尼碱受体通道的调节涉及肌浆网腔Ca2+传感位点。
Biophys J. 1998 Dec;75(6):2801-10. doi: 10.1016/S0006-3495(98)77723-9.
5
Inactivation of Ca2+ release channels (ryanodine receptors RyR1 and RyR2) with rapid steps in [Ca2+] and voltage.通过快速改变[Ca2+]和电压来使Ca2+释放通道（雷诺丁受体RyR1和RyR2）失活。
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6
Sulfhydryl oxidation modifies the calcium dependence of ryanodine-sensitive calcium channels of excitable cells.巯基氧化改变了可兴奋细胞中对ryanodine敏感的钙通道的钙依赖性。
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7
Termination of Ca2+ release during Ca2+ sparks in rat ventricular myocytes.大鼠心室肌细胞中钙火花期间钙释放的终止。
J Physiol. 1998 Mar 15;507 ( Pt 3)(Pt 3):667-77. doi: 10.1111/j.1469-7793.1998.667bs.x.
8
Heterogeneity of Ca2+ gating of skeletal muscle and cardiac ryanodine receptors.骨骼肌和心肌兰尼碱受体Ca2+门控的异质性。
Biophys J. 1997 Jul;73(1):141-56. doi: 10.1016/S0006-3495(97)78055-X.
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'Quantal' calcium release operated by membrane voltage in frog skeletal muscle.蛙骨骼肌中由膜电压操控的“量子化”钙释放。
J Physiol. 1997 Jun 1;501 ( Pt 2)(Pt 2):289-303. doi: 10.1111/j.1469-7793.1997.289bn.x.
10
Sarcoplasmic reticulum Ca2+ release flux underlying Ca2+ sparks in cardiac muscle.心肌中钙火花背后的肌浆网Ca2+释放通量。
Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4176-81. doi: 10.1073/pnas.94.8.4176.