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The biology of Epstein-Barr virus: lessons learned from the virus and the host.

作者信息

Cohen J I

机构信息

Medical Virology Section, Laboratory of Clinical Investigation, Building 10, Room 11N214, National Institutes of Health Bethesda, MD 20892, USA.

出版信息

Curr Opin Immunol. 1999 Aug;11(4):365-70. doi: 10.1016/S0952-7915(99)80062-4.

DOI:10.1016/S0952-7915(99)80062-4
PMID:10448133
Abstract

Recent studies indicate that a large proportion of cytotoxic T cells are directed towards the Epstein-Barr virus (EBV) during both acute infection and convalescence. The virus, in turn, has usurped cellular pathways to promote proliferation of infected cells and has pirated cellular genes into its genome to modulate the immune system to allow lifelong infection of humans. Analysis of the immune response to the virus is leading to novel therapies for EBV-associated malignancies, including the use of virus-specific cytotoxic T cell infusions.

摘要

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