Rickinson A B, Callan M F, Annels N E
CRC Institute for Cancer Studies, University of Birmingham, Edgbaston, UK.
Philos Trans R Soc Lond B Biol Sci. 2000 Mar 29;355(1395):391-400. doi: 10.1098/rstb.2000.0579.
Epstein-Barr virus offers an ideal opportunity to follow the human T-cell response to a virus infection over time from its acute primary phase, as seen in infectious mononucleosis patients, into the memory phase that accompanies life-long virus persistence. Here we review recent evidence on the development and maturation of cytotoxic T-cell memory using this viral system.
爱泼斯坦-巴尔病毒提供了一个理想的契机，可用于追踪人类T细胞对病毒感染的反应随时间的变化，从其急性初始阶段（如传染性单核细胞增多症患者所见），直至伴随病毒终身持续存在的记忆阶段。在此，我们回顾了利用该病毒系统在细胞毒性T细胞记忆的发育和成熟方面的最新证据。
