Brander C, Walker B D
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, MGH-East, 5th floor, 149 13th Street, Charlestown, MA 02129, USA.
Curr Opin Immunol. 1999 Aug;11(4):451-9. doi: 10.1016/S0952-7915(99)80076-4.
Substantial progress has been made over the past year in understanding the cellular immune response in HIV pathogenesis. Cytotoxic T lymphocytes play a critical role in establishing the level of viremia and virus-specific Th cell responses appear to affect the in vivo efficacy of cytotoxic T lymphocytes. Together, these new data provide important insights to refocus efforts aimed at immunotherapeutic interventions and vaccine development.
在过去一年里，我们对HIV发病机制中的细胞免疫反应的理解取得了重大进展。细胞毒性T淋巴细胞在确定病毒血症水平方面起着关键作用，而病毒特异性Th细胞反应似乎会影响细胞毒性T淋巴细胞的体内疗效。这些新数据共同为重新聚焦免疫治疗干预和疫苗开发的努力提供了重要见解。
