艾滋病病毒感染中的免疫发病机制与免疫治疗

Immunopathogenesis and immunotherapy in AIDS virus infections.

作者信息

Letvin Norman L, Walker Bruce D

机构信息

Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

出版信息

Nat Med. 2003 Jul;9(7):861-6. doi: 10.1038/nm0703-861.

DOI:10.1038/nm0703-861

PMID:12835706

Abstract

The heterogeneity of HIV and the different human leukocyte antigen (HLA) backgrounds of infected individuals have posed challenges to understanding the pathogenesis of HIV infection. But continuing advances in our knowledge of the role of immune responses in controlling HIV viremia should help to define goals for immune-based therapies and vaccine strategies against AIDS.

摘要

人类免疫缺陷病毒（HIV）的异质性以及受感染个体不同的人类白细胞抗原（HLA）背景给理解HIV感染的发病机制带来了挑战。但是，我们对免疫反应在控制HIV病毒血症中作用的认识不断进步，这应有助于明确针对艾滋病的免疫疗法和疫苗策略的目标。