Mason P
Department of Neurobiology, Pharmacology and Physiology, Committee on Neurobiology, The University of Chicago, 947 East 58th Street, Chicago, Illinois 60637, USA.
Curr Opin Neurobiol. 1999 Aug;9(4):436-41. doi: 10.1016/S0959-4388(99)80065-8.
Bulbospinal serotonergic neurons and two physiological classes of bulbospinal nonserotonergic cells interact to modulate pain transmission. Recent studies have begun to elaborate targets of descending pain modulation other than the well-studied flexion withdrawal pathways. Site-specific, naloxone-sensitive placebo analgesia, which is hard to reconcile with current models of descending pain modulation, presents an exciting challenge to the field.
延髓脊髓5-羟色胺能神经元与两类生理性的延髓脊髓非5-羟色胺能细胞相互作用，以调节痛觉传递。最近的研究已开始阐述除了已得到充分研究的屈肌反射通路之外的下行性痛觉调制靶点。位点特异性、纳洛酮敏感的安慰剂镇痛难以与当前的下行性痛觉调制模型相协调，这给该领域带来了令人兴奋的挑战。
