Khanna S, Sinclair J G
Gen Pharmacol. 1987;18(3):287-92. doi: 10.1016/0306-3623(87)90013-9.
Morphine sulphate, administered in three cumulative doses (0.5, 1.0, and 2.0 mg/kg, i.v.) to alpha-chloralose anaesthetized cats, reduced the nociceptive activity of deep dorsal horn multireceptive neurones but failed to alter the descending nucleus raphe magnus (NRM) phasic inhibition of these neurones. Morphine was also administered to fluoxetine (6.0 mg/kg, i.v.) pretreated animals. Fluoxetine is a selective 5-hydroxytryptamine (5-HT) uptake blocker, which should enhance 5-HT synaptic transmission. In these animals, morphine suppressed the neuronal nociceptive activity to the same extent as seen with morphine alone and did not affect the NRM inhibition. These results do not support the notion that morphine activates a descending serotonergic inhibition from the NRM or that serotonin mediates morphine inhibition of spinal nociceptive transmission in cats.
给用α-氯醛糖麻醉的猫静脉注射硫酸吗啡，分三个累积剂量（0.5、1.0和2.0毫克/千克），可降低脊髓背角深层多感受神经元的伤害性活动，但未能改变中缝大核（NRM）对这些神经元的相位性抑制。还对用氟西汀（6.0毫克/千克，静脉注射）预处理的动物注射吗啡。氟西汀是一种选择性5-羟色胺（5-HT）摄取阻滞剂，应能增强5-HT突触传递。在这些动物中，吗啡抑制神经元伤害性活动的程度与单独使用吗啡时相同，且不影响NRM的抑制作用。这些结果不支持吗啡激活来自NRM的下行5-羟色胺能抑制或5-羟色胺介导吗啡对猫脊髓伤害性传递抑制作用的观点。
