Wang Y C, Lee H S, Chen S K, Chang Y Y, Chen C Y
Institute of Toxicology, Chung Shan Medical and Dental College, Taichung, Taiwan, Republic of China.
Eur J Cancer. 1999 Feb;35(2):226-30. doi: 10.1016/s0959-8049(98)00369-4.
Lung cancer is the leading cause of cancer death in Taiwan. Potential molecular markers associated with cancer susceptibility and prognosis are the genes involved in tumorigenesis. Therefore, we investigated the association of p53 codon 72 polymorphism with prognosis in 114 lung cancer patients. The estimated median survival times for patients with proline (Pro)/Pro, arginine (Arg)/Arg, and Arg/Pro genotypes were 25, 26 and 36 months, respectively. We also found that patients with the Pro/Pro genotype had a worse prognosis compared with those with Arg/Pro genotypes, especially for patients with squamous cell lung cancer (P = 0.013), male patients (P = 0.028) and those aged 60-69 years (P = 0.052). In patients with early stage lung cancer, patients with Pro/Pro and Arg/Arg genotypes had a tendency for a worse prognosis than those with the Arg/Pro genotype (P = 0.057). Our data suggest that p53 codon 72 polymorphism may be a potential prognostic factor in certain sub groups of lung cancer patients in Taiwan.
肺癌是台湾癌症死亡的主要原因。与癌症易感性和预后相关的潜在分子标志物是参与肿瘤发生的基因。因此，我们研究了114例肺癌患者中p53密码子72多态性与预后的关系。脯氨酸（Pro）/Pro、精氨酸（Arg）/Arg和Arg/Pro基因型患者的估计中位生存时间分别为25、26和36个月。我们还发现，与Arg/Pro基因型患者相比，Pro/Pro基因型患者的预后更差，尤其是鳞状细胞肺癌患者（P = 0.013）、男性患者（P = 0.028）和60 - 69岁患者（P = 0.052）。在早期肺癌患者中，Pro/Pro和Arg/Arg基因型患者的预后往往比Arg/Pro基因型患者更差（P = 0.057）。我们的数据表明，p53密码子72多态性可能是台湾部分肺癌患者亚组中的一个潜在预后因素。
