Maslovsky I, Lugassy G, Blumental R, Ducach A, Yehuda O, Abeliovich D
Hematology Institute, Barzilai Medical Center, Ashkelon, Israel.
Clin Lab Haematol. 1999 Jun;21(3):207-10. doi: 10.1046/j.1365-2257.1999.00207.x.
We describe a 58-year-old woman with anaplastic multiple myeloma and multiple chromosomal abnormalities. Her karyotype showed extreme hyperploidy with 77 chromosomes. Some of the aberrations were typical of multiple myeloma (+3, +5, +15, +19, +21, t(11;14)(q13;q32)), others were characteristic of the aggressive anaplastic myeloma (+8), t(11;14)(q13;q32), while three chromosomal abnormalities (t(11;20)(p11;q13); t(4;7)(q31;q11); and t(14;20)(q24;q13)) have not been, to the best of our knowledge, described previously in the literature. The fulminant course of the disease confirms the poor prognosis of multiple karyotypic abnormalities in myeloma.
我们描述了一名患有间变性多发性骨髓瘤和多种染色体异常的58岁女性。她的核型显示为具有77条染色体的极端超二倍体。其中一些畸变是多发性骨髓瘤的典型特征（+3、+5、+15、+19、+21、t(11;14)(q13;q32)），其他的是侵袭性间变性骨髓瘤的特征（+8）、t(11;14)(q13;q32)，而据我们所知，三种染色体异常（t(11;20)(p11;q13)；t(4;7)(q31;q11)；以及t(14;20)(q24;q13)）此前在文献中未曾有过描述。该疾病的暴发性病程证实了骨髓瘤中多种核型异常的预后不良。
