Gould J, Alexanian R, Goodacre A, Pathak S, Hecht B, Barlogie B
University of Texas, M.D. Anderson Hospital & Tumor Institute, Houston 77030.
Blood. 1988 Feb;71(2):453-6.
Karyotypic abnormalities were studied in multiple myeloma and were correlated with clinical features. Among 115 evaluable patients, 46% had an abnormal karyotype. Trisomy 3, 5, 9, and 15 and monosomy 13 and 16 were the most common clonal abnormalities. Translocations described previously in other B cell malignancies occurred in nine patients, including four with t(8;14)(q24;q32) translocations. The association of all t(8;14) abnormalities with IgA protein type suggested a pathogenetic relationship between a specific karyotypic abnormality and myeloma protein type. Hypodiploidy occurred mainly in patients with only Bence Jones protein, was associated with resistance to therapy, and justified the early consideration of investigational therapies.
对多发性骨髓瘤的核型异常进行了研究，并将其与临床特征相关联。在115例可评估患者中，46%的患者核型异常。三体3、5、9和15以及单体13和16是最常见的克隆性异常。先前在其他B细胞恶性肿瘤中描述的易位发生在9例患者中，包括4例t(8;14)(q24;q32)易位。所有t(8;14)异常与IgA蛋白类型的关联提示特定核型异常与骨髓瘤蛋白类型之间存在致病关系。亚二倍体主要发生在仅产生本周氏蛋白的患者中，与治疗抵抗相关，这为早期考虑试验性治疗提供了依据。
