Jadallah F, McCall J L, van Rij A M
Department of Surgery, Dunedin School of Medicine.
N Z Med J. 1999 Jul 9;112(1091):248-50.
To measure long-term outcomes in an unselected consecutive series of patients undergoing potentially curative surgery for colorectal cancer at Dunedin Hospital and identify risk factors for disease recurrence and mortality.
A retrospective study of 241 patients operated on between January 1990 and December 1992, and followed up to January 1996.
Overall five-year actuarial survival was 55 percent, and 66, 56 and 43 percent respectively for Dukes' stage A, B and C disease. Factors associated with increased overall mortality were advanced Dukes' stage, perioperative blood transfusion and smoking, whereas factors associated with disease recurrence were advanced Dukes' stage, large tumour size and presentation with obstruction.
Mortality following potentially curative surgery for colorectal cancer in Dunedin has not changed significantly since the previous study 15 years earlier and is similar to more recently published data from other New Zealand centres.
对在达尼丁医院接受结直肠癌潜在根治性手术的一系列未经选择的连续患者进行长期预后评估，并确定疾病复发和死亡的危险因素。
对1990年1月至1992年12月期间接受手术的241例患者进行回顾性研究，并随访至1996年1月。
总体五年精算生存率为55%，杜克A、B、C期疾病的五年精算生存率分别为66%、56%和43%。与总体死亡率增加相关的因素有杜克分期较晚、围手术期输血和吸烟，而与疾病复发相关的因素有杜克分期较晚、肿瘤体积较大和伴有肠梗阻。
自达尼丁上一次研究（15年前）以来，结直肠癌潜在根治性手术后的死亡率没有显著变化，且与新西兰其他中心最近公布的数据相似。
