Di Fiore P P, Gill G N
Istituto Europeo di Oncologia, Via Ripamonti 435, 20141, Milan, Italy.
Curr Opin Cell Biol. 1999 Aug;11(4):483-8. doi: 10.1016/s0955-0674(99)80069-6.
Is there mitogenic signaling during endocytosis or is receptor internalization mainly an attenuator of signals? Recent data indicate that the answer appears to be yes to both questions. Signal transduction occurs physiologically from the cell surface and endocytosis downregulates signaling by removing receptors from the plasma membrane. In cancer, the involvement of endocytic/sorting proteins points to dysregulation of apparently unrelated pathways, which might account for an important causative role in neoplasia.
在胞吞作用过程中是否存在促有丝分裂信号，或者受体内化主要是信号的衰减器？最近的数据表明，这两个问题的答案似乎都是肯定的。信号转导在生理上从细胞表面发生，而胞吞作用通过从质膜上去除受体来下调信号传导。在癌症中，内吞/分选蛋白的参与表明明显不相关的途径失调，这可能是肿瘤形成的一个重要致病因素。
