Faiella Antonio, Riccardi Ferdinando, Cartenì Giacomo, Chiurazzi Martina, Onofrio Livia
Department of Medical Oncology, AO "A. Cardarelli", Naples, Italy.
Department of Radiology, Oncology and Pathology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
J Oncol. 2022 Jan 13;2022:5179182. doi: 10.1155/2022/5179182. eCollection 2022.
c-MET is a receptor tyrosine kinase receptor (RTK) for the hepatocyte growth factor (HGF). The binding of HGF to c-MET regulates several cellular functions: differentiation, proliferation, epithelial cell motility, angiogenesis, and epithelial-mesenchymal transition (EMT). Moreover, it is known to be involved in carcinogenesis. Comprehension of HGF-c-MET signaling pathway might have important clinical consequences allowing to predict prognosis, response to treatment, and survival rates based on its expression and dysregulation. . c-MET represents a useful molecular target for novel engineered drugs. Several clinical trials are underway for various solid tumors and the development of new specific monoclonal antibodies depends on the recent knowledge about the definite c-MET role in each different malignance. Recent clinical trials based on c-MET molecular targets result in good safety profile and represent a promising therapeutic strategy for solid cancers, in monotherapy or in combination with other target drugs.
The list of cell surface receptors crosslinking with the c-MET signaling is constantly growing, highlighting the importance of this pathway for personalized target therapy. Research on the combination of c-MET inhibitors with other drugs will hopefully lead to discovery of new effective treatment options.
c-MET是肝细胞生长因子（HGF）的受体酪氨酸激酶受体（RTK）。HGF与c-MET的结合调节多种细胞功能：分化、增殖、上皮细胞迁移、血管生成以及上皮-间质转化（EMT）。此外，已知其参与致癌过程。了解HGF-c-MET信号通路可能具有重要的临床意义，能够根据其表达和失调情况预测预后、治疗反应及生存率。c-MET是新型工程药物的一个有用分子靶点。针对多种实体瘤的多项临床试验正在进行，新型特异性单克隆抗体的研发取决于对c-MET在每种不同恶性肿瘤中确切作用的最新认识。基于c-MET分子靶点的近期临床试验具有良好的安全性，代表了实体癌单药治疗或与其他靶向药物联合治疗的一种有前景的治疗策略。
与c-MET信号交联的细胞表面受体列表不断增加，凸显了该通路在个性化靶向治疗中的重要性。c-MET抑制剂与其他药物联合应用的研究有望带来新的有效治疗方案。
