Shields D, Arvan P
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Curr Opin Cell Biol. 1999 Aug;11(4):489-94. doi: 10.1016/s0955-0674(99)80070-2.
Over the past two years, the use of in vitro systems and the identification of autoantibodies to Golgi proteins have provided important new tools for analyzing vesicle and cargo trafficking in the distal secretory pathway. In addition, the phenotypic characterization of mice with knockouts of various prohormone convertases has led to significant progress in understanding the biological relevance of prohormone processing in post-Golgi compartments.
在过去两年中，体外系统的应用以及针对高尔基体蛋白自身抗体的鉴定为分析远端分泌途径中的囊泡和货物运输提供了重要的新工具。此外，各种激素原转化酶基因敲除小鼠的表型特征分析，在理解高尔基体后区室中激素原加工的生物学意义方面取得了重大进展。
