Arias A M, Brown A M, Brennan K
Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK.
Curr Opin Genet Dev. 1999 Aug;9(4):447-54. doi: 10.1016/s0959-437x(99)80068-9.
Members of the Wnt family of secreted glycoproteins participate in many signalling events during development. Recent findings suggest that Wnt signals can sometimes play a permissive role during cell-fate assignment. Wnt proteins have been shown to interact with a number of extracellular and cell-surface proteins, whereas many intracellular components of the Wnt-signalling pathway are also involved in other cellular functions. The consequences of Wnt signalling can be affected by members of the MAP kinase family. These observations suggest that the future understanding of Wnt signalling may require models that are based on a signalling network rather than a single linear pathway.
分泌型糖蛋白Wnt家族的成员在发育过程中参与许多信号传导事件。最近的研究结果表明，Wnt信号有时在细胞命运决定过程中起许可作用。已证明Wnt蛋白可与多种细胞外和细胞表面蛋白相互作用，而Wnt信号通路的许多细胞内成分也参与其他细胞功能。Wnt信号传导的后果可能受丝裂原活化蛋白激酶（MAP）家族成员的影响。这些观察结果表明，未来对Wnt信号传导的理解可能需要基于信号网络而非单一线性途径的模型。
