Agarwala R, Biesecker L G, Tomlin J F, Schäffer A A
Inherited Diseases Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892-4472, USA.
Am J Med Genet. 1999 Sep 10;86(2):156-61. doi: 10.1002/(sici)1096-8628(19990910)86:2<156::aid-ajmg13>3.0.co;2-5.
Genetic studies on closed populations benefit from comprehensive, searchable genealogy resources. To support studies of Anabaptists, a computerized database has been developed that merges two large genealogy books, the "Fisher Family History" and the "Amish and Amish Mennonite Genealogies." The former is more current but the latter is more comprehensive for the 18th and 19th centuries. Therefore, the merger of the two books is significantly more useful than either book alone. We demonstrate the utility of the merged database with two results: an increase in inbreeding coefficients and the identification of parent-child relationships that do not exist in either book. Am. J. Med. Genet. 86:156-161, 1999. Published 1999 Wiley-Liss, Inc.
对封闭人群的基因研究受益于全面且可搜索的族谱资源。为了支持对再洗礼派的研究,已开发出一个计算机化数据库,该数据库合并了两本大型族谱书籍,即《费舍尔家族史》和《阿米什人与阿米什门诺派族谱》。前者更新,但后者在18和19世纪更为全面。因此,两本书合并后比单独的任何一本书都有用得多。我们通过两个结果展示了合并后数据库的效用:近亲繁殖系数的增加以及识别出两本书中都不存在的亲子关系。《美国医学遗传学杂志》86:156 - 161,1999年。1999年由威利 - 利斯公司出版。