Kochunov Peter, Thompson Paul M, Winkler Anderson, Morrissey Mary, Fu Mao, Coyle Thomas R, Du Xiaoming, Muellerklein Florian, Savransky Anya, Gaudiot Christopher, Sampath Hemalatha, Eskandar George, Jahanshad Neda, Patel Binish, Rowland Laura, Nichols Thomas E, O'Connell Jeffrey R, Shuldiner Alan R, Mitchell Braxton D, Hong L Elliot
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Imaging Genetics Center, Keck School of Medicine of USC, Marina del Rey, CA, USA.
Neuroimage. 2016 Jan 15;125:189-197. doi: 10.1016/j.neuroimage.2015.10.050. Epub 2015 Oct 21.
Speed with which brain performs information processing influences overall cognition and is dependent on the white matter fibers. To understand genetic influences on processing speed and white matter FA, we assessed processing speed and diffusion imaging fractional anisotropy (FA) in related individuals from two populations. Discovery analyses were performed in 146 individuals from large Old Order Amish (OOA) families and findings were replicated in 485 twins and siblings of the Human Connectome Project (HCP). The heritability of processing speed was h(2)=43% and 49% (both p<0.005), while the heritability of whole brain FA was h(2)=87% and 88% (both p<0.001), in the OOA and HCP, respectively. Whole brain FA was significantly correlated with processing speed in the two cohorts. Quantitative genetic analysis demonstrated a significant degree to which common genes influenced joint variation in FA and brain processing speed. These estimates suggested common sets of genes influencing variation in both phenotypes, consistent with the idea that common genetic variations contributing to white matter may also support their associated cognitive behavior.
大脑执行信息处理的速度会影响整体认知，且依赖于白质纤维。为了解基因对处理速度和白质各向异性分数（FA）的影响，我们评估了来自两个人群的相关个体的处理速度和扩散成像各向异性分数（FA）。在来自大型老派阿米什人（OOA）家庭的146名个体中进行了发现分析，并在人类连接组计划（HCP）的485对双胞胎和兄弟姐妹中进行了结果验证。在OOA和HCP中，处理速度的遗传力分别为h(2)=43%和49%（均p<0.005），而全脑FA的遗传力分别为h(2)=87%和88%（均p<0.001）。在两个队列中，全脑FA与处理速度显著相关。数量遗传学分析表明，常见基因在很大程度上影响了FA和大脑处理速度的联合变异。这些估计表明，影响两种表型变异的常见基因集是一致的，这与以下观点一致，即导致白质变化的常见遗传变异也可能支持其相关的认知行为。
