维甲酸、乙醇酸和水杨酸亲脂性衍生物对光损伤表皮的比较作用。
Comparative effects of retinoic acid, glycolic acid and a lipophilic derivative of salicylic acid on photodamaged epidermis.
作者信息
Pi rard G E, Kligman A M, Stoudemayer T, Lévêque J L
机构信息
Department of Dermatopathology, University of Liège, Belgium.
出版信息
Dermatology. 1999;199(1):50-3. doi: 10.1159/000018178.
BACKGROUND
Studies comparing purported antiaging compounds are rare.
OBJECTIVE
To compare in a randomized, placebo-controlled double-blind study 10% glycolic acid (GA), 2% 2-hydroxy-5-octanoyl benzoic acid (beta-lipohydroxy acid, LSA) and 0.05% all-trans-retinoic acid (RA).
METHODS
Women volunteers treated one forearm twice daily with one of the active products and the other one with the vehicle. Comparative evaluations of efficacy were made using histochemistry and quantitative immunohistochemistry.
RESULTS
Improvement in the various epidermal compartments was the most prominent finding at the RA-treated site. The LSA-treated site also exhibited similar positive changes, although to a lesser degree. GA showed no significant effect.
CONCLUSION
In the presently tested concentrations and formulations, RA had a beneficial impact upon the aging epidermis. LSA mimicked RA but with somewhat lesser efficacy. By contrast, GA appeared almost inactive.
背景
比较所谓抗衰老化合物的研究很少。
目的
在一项随机、安慰剂对照双盲研究中比较10%乙醇酸（GA）、2%2-羟基-5-辛酰基苯甲酸（β-脂羟酸，LSA）和0.05%全反式维甲酸（RA）。
方法
女性志愿者每天两次用一种活性产品处理一侧前臂，另一侧用赋形剂处理。使用组织化学和定量免疫组织化学进行疗效的比较评估。
结果
在RA处理部位，各表皮层的改善最为显著。LSA处理部位也表现出类似的积极变化，尽管程度较小。GA没有显著效果。
结论
在目前测试的浓度和配方中，RA对老化表皮有有益影响。LSA模拟了RA，但效果稍差。相比之下，GA几乎没有活性。
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