Carter P G, Cannon A, McConnell A A, Abrams P
Bristol Urological Institute, Southmead Hospital, Bristol, UK.
Eur Urol. 1999 Sep;36(3):213-20. doi: 10.1159/000068000.
To demonstrate nocturnal polyuria objectively and to assess the role of atrial natriuretic peptide (ANP) in healthy elderly males with and without nocturnal polyuria (NP).
31 healthy elderly men known to have NP (passing more than 33% of their 24-hour urine output during an 8-hour period overnight) and 12 controls without NP were invited to take part in the study. Blood and urine samples were collected at 4-hourly intervals in order to measure urine output, serum and urine electrolytes and osmolality as well as serum cortisol, renin, aldosterone, arginine vasopressin (AVP) and ANP.
26 men with NP and 8 controls agreed to take part in the study. Subjects with NP were found to have a diuresis and natriuresis as well as a significant increase in ANP overnight compared to the control group. There was no difference in the other parameters between the 3 groups, with the exception of aldosterone and AVP.
This study has shown a group of subjects with increased natriuresis and diuresis overnight, associated with an increase in ANP. It is possible that subclinical cardiac failure causes an increase in ANP therefore causing nocturnal urinary symptoms and this theory needs further exploration.
客观证明夜间多尿，并评估心房利钠肽（ANP）在有或无夜间多尿（NP）的健康老年男性中的作用。
邀请31名已知有夜间多尿（夜间8小时内排尿量超过24小时总尿量的33%）的健康老年男性和12名无夜间多尿的对照者参与研究。每隔4小时采集血液和尿液样本，以测量尿量、血清和尿液电解质及渗透压，以及血清皮质醇、肾素、醛固酮、精氨酸加压素（AVP）和ANP。
26名有夜间多尿的男性和8名对照者同意参与研究。与对照组相比，有夜间多尿的受试者夜间出现利尿、利钠现象，且ANP显著增加。除醛固酮和AVP外，三组间其他参数无差异。
本研究显示了一组夜间利钠和利尿增加且伴有ANP升高的受试者。亚临床心力衰竭可能导致ANP升高，进而引起夜间泌尿症状，这一理论有待进一步探索。
