Division of Urology, Department of Surgery, Taipei City Hospital, Renai Branch, Taipei, Taiwan.
Division of Urology, Department of Surgery, Taipei City Hospital, Zhongxiao Branch, Taipei, Taiwan.
Sci Rep. 2022 Sep 1;12(1):14897. doi: 10.1038/s41598-022-19190-9.
Nocturia can be caused by urological disorders and systemic diseases, including heart diseases. We aimed to investigate the relationship between nocturia and structural abnormalities on echocardiography. Adult patients who underwent echocardiography for cardiac symptoms or heart murmur or had a history of structural heart disease were included. The voiding times during sleep hours were collected prospectively. Univariate and multivariate analyses were performed to evaluate the predictive value of bothersome nocturia (nocturia ≥ 2) on echocardiographic abnormalities. Of 299 patients, 182 (60.9%) reported bothersome nocturia. In patients aged ≥ 65 years, hypertension and left atrial enlargement (LAE) were associated with higher occurrences of bothersome nocturia. On multivariate analysis, bothersome nocturia was a predictive factor of LAE (odds ratio [OR] 2.453, 95% confidence interval [CI] 1.363-4.416, p = 0.003). Moreover, bothersome nocturia could predict both LAE and left ventricular hypertrophy (LVH) (OR 2.285, 95% CI 1.151-4.536, p = 0.018; OR 2.056, 95% CI 1.025-4.124, p = 0.043) in the elderly. Older age, hypertension, and LAE were risk factors for bothersome nocturia. Moreover, bothersome nocturia was predictive of LAE and LVH in the elderly. Patients with bothersome nocturia without other significant lower urinary tract symptoms should be referred to cardiologists.
夜尿症可由泌尿系统疾病和全身性疾病引起，包括心脏病。我们旨在研究夜尿症与超声心动图结构异常之间的关系。纳入因心脏症状、心脏杂音或结构性心脏病史而行超声心动图检查的成年患者。前瞻性收集睡眠期间的排尿次数。进行单变量和多变量分析，以评估烦扰性夜尿症（夜尿症≥2 次）对超声心动图异常的预测价值。在 299 例患者中，182 例（60.9%）报告有烦扰性夜尿症。在年龄≥65 岁的患者中，高血压和左心房扩大（LAE）与烦扰性夜尿症的发生率较高相关。多变量分析显示，烦扰性夜尿症是 LAE 的预测因素（比值比 [OR] 2.453，95%置信区间 [CI] 1.363-4.416，p=0.003）。此外，烦扰性夜尿症可预测 LAE 和左心室肥厚（LVH）（OR 2.285，95%CI 1.151-4.536，p=0.018；OR 2.056，95%CI 1.025-4.124，p=0.043）在老年人中。年龄较大、高血压和 LAE 是烦扰性夜尿症的危险因素。此外，烦扰性夜尿症是老年人 LAE 和 LVH 的预测因素。无其他明显下尿路症状的烦扰性夜尿症患者应转介给心脏病专家。
