未用药的精神分裂症患者颞叶中磷代谢物水平的变化。
Changes in levels of phosphorus metabolites in temporal lobes of drug-naive schizophrenic patients.
作者信息
Fukuzako H, Fukuzako T, Hashiguchi T, Kodama S, Takigawa M, Fujimoto T
机构信息
Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, Japan.
出版信息
Am J Psychiatry. 1999 Aug;156(8):1205-8. doi: 10.1176/ajp.156.8.1205.
OBJECTIVE
The authors examined phospholipids and high-energy phosphorus metabolism in the temporal lobes of drug-naive schizophrenic patients.
METHOD
In vivo 31P magnetic resonance spectroscopy was performed on 17 first-episode, drug-naive schizophrenic patients and 17 age- and gender-matched healthy subjects.
RESULTS
Patients showed higher levels of phosphodiesters and lower levels of phosphomonoesters than the comparison group. Phosphocreatine levels were increased in the left temporal lobes of patients.
CONCLUSIONS
The results suggest disturbed membrane phospholipid metabolism in both temporal lobes and decreased energy demands in the left temporal lobes of drug-naive schizophrenic patients.
目的
作者研究了未服用过药物的精神分裂症患者颞叶中的磷脂和高能磷代谢。
方法
对17例首发、未服用过药物的精神分裂症患者及17名年龄和性别匹配的健康受试者进行了活体31P磁共振波谱分析。
结果
与对照组相比，患者的磷酸二酯水平较高，磷酸单酯水平较低。患者左颞叶中的磷酸肌酸水平升高。
结论
结果表明，未服用过药物的精神分裂症患者双侧颞叶存在膜磷脂代谢紊乱，左颞叶能量需求降低。
Zotero 插件