精神分裂症中的磷磁共振波谱分析：颞叶膜磷脂代谢与阳性症状之间的相关性

Phosphorus magnetic resonance spectroscopy in schizophrenia: correlation between membrane phospholipid metabolism in the temporal lobe and positive symptoms.

Fukuzako H, Fukuzako T, Takeuchi K, Ohbo Y, Ueyama K, Takigawa M, Fujimoto T

Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, Japan.

Prog Neuropsychopharmacol Biol Psychiatry. 1996 May;20(4):629-40. doi: 10.1016/0278-5846(96)00036-x.

Abstract

To determine any correlations between phosphorus metabolites in the temporal lobes and clinical symptoms in schizophrenic patients, the authors performed 31phosphorus magnetic resonance spectroscopy in 31 medicated patients and age- and sex- matched normal subjects. 2. Schizophrenic patients demonstrated an increased level of phosphodiesters (PDE) in the temporal lobes bilaterally and a decreased level of beta-adenosine triphosphate (beta-ATP) in the left temporal lobe. 3. A significant positive correlation was observed between the level of PDE in the left temporal lobe and the score of positive symptoms on the Brief Psychiatric Rating Scale. 4. These results suggest that altered membrane phospholipid metabolism in the left temporal lobe is associated with neuroleptic-resistant positive symptoms in schizophrenic patients.

摘要

为了确定精神分裂症患者颞叶中磷代谢物与临床症状之间的相关性，作者对31名正在服药的患者以及年龄和性别匹配的正常受试者进行了磷磁共振波谱分析。2. 精神分裂症患者双侧颞叶中的磷酸二酯（PDE）水平升高，左侧颞叶中的β-三磷酸腺苷（β-ATP）水平降低。3. 观察到左侧颞叶中PDE水平与简明精神病评定量表上的阳性症状评分之间存在显著正相关。4. 这些结果表明，左侧颞叶中膜磷脂代谢的改变与精神分裂症患者对抗精神病药物耐药的阳性症状有关。