慢性精神分裂症患者基底神经节的磷代谢
Basal ganglia phosphorous metabolism in chronic schizophrenia.
作者信息
Deicken R F, Calabrese G, Merrin E L, Fein G, Weiner M W
机构信息
Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121.
出版信息
Am J Psychiatry. 1995 Jan;152(1):126-9. doi: 10.1176/ajp.152.1.126.
OBJECTIVE
The authors examined whether there are abnormalities in high-energy phosphorous metabolism in the basal ganglia of schizophrenic patients.
METHOD
In vivo 31P magnetic resonance spectroscopic imaging was performed on 18 chronic schizophrenic patients and 16 healthy comparison subjects. The percentages of total phosphorous signal for phosphomonoesters, inorganic phosphate, phosphodiesters, phosphocreatine, and beta-ATP were calculated.
RESULTS
The mean percentages of beta-ATP signal in the right and left basal ganglia were significantly lower for the schizophrenic patients than for the comparison group. No other group differences in phosphorous metabolites and no lateral asymmetries in the schizophrenic group were noted.
CONCLUSIONS
This preliminary study provides support for abnormal high-energy phosphorous metabolism in the basal ganglia of schizophrenic patients.
目的
作者研究了精神分裂症患者基底神经节中高能磷代谢是否存在异常。
方法
对18名慢性精神分裂症患者和16名健康对照者进行了体内31P磁共振波谱成像。计算了磷酸单酯、无机磷酸盐、磷酸二酯、磷酸肌酸和β-ATP的总磷信号百分比。
结果
精神分裂症患者左右基底神经节中β-ATP信号的平均百分比显著低于对照组。未发现磷代谢物的其他组间差异，且精神分裂症组未观察到左右侧不对称。
结论
这项初步研究为精神分裂症患者基底神经节中异常的高能磷代谢提供了支持。
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