Tromp A M, Smit J H, Deeg D J, Lips P
Institute for Research in Extramural Medicine (EMGO Institute), Vrije Universiteit, Amsterdam, The Netherlands.
Osteoporos Int. 1999;9(3):230-5. doi: 10.1007/s001980050142.
The performance of quantitative ultrasound (QUS) measurements of the tibia and calcaneus was studied in 109 elderly people (age range 65-87 years). Broadband ultrasound attenuation (BUA) and speed of sound (SOS) were measured at the calcaneus and SOS was assessed at the tibia. Short-term precision of tibial QUS was studied in 16 volunteers. The coefficient of variation (CV) was 0.4% and the standardized CV (sCV) was 4.4%. We compared the calcaneal and tibial QUS measurements with bone mineral density (BMD) measurements of the lumbar spine, femoral neck, trochanter and total body assessed by dual-energy X-ray absorptiometry (DXA). Calcaneal QUS correlated better with BMD at various skeletal sites than tibial QUS. Calcaneal BUA showed higher correlations with BMD values of the lumbar spine, femoral neck, trochanter and total body than calcaneal and tibial SOS (r = 0.48-0.64, r = 0.30-0.47, r = 0.35-0.47, respectively; p < 0.001). Body weight modified the relationships between calcaneal and tibial QUS and BMD measurements of the hip. Higher body weight was associated with higher BMD values at the femoral neck and trochanter for the same calcaneal and tibial QUS values. After adjustments for body weight correlations of tibial and calcaneal QUS with BMD improved and were very similar. This suggests that correction for body weight is important and could add to the predictive value of QUS measurements.
对109名老年人（年龄范围65 - 87岁）进行了胫骨和跟骨定量超声（QUS）测量性能的研究。测量了跟骨的宽带超声衰减（BUA）和声速（SOS），并评估了胫骨的SOS。在16名志愿者中研究了胫骨QUS的短期精度。变异系数（CV）为0.4%，标准化变异系数（sCV）为4.4%。我们将跟骨和胫骨的QUS测量结果与通过双能X线吸收法（DXA）评估的腰椎、股骨颈、大转子和全身的骨密度（BMD）测量结果进行了比较。跟骨QUS与各个骨骼部位的BMD相关性比胫骨QUS更好。跟骨BUA与腰椎、股骨颈、大转子和全身的BMD值的相关性高于跟骨和胫骨的SOS（r分别为0.48 - 0.64、0.30 - 0.47、0.35 - 0.47；p < 0.001）。体重改变了跟骨和胫骨QUS与髋部BMD测量之间的关系。对于相同的跟骨和胫骨QUS值，较高的体重与股骨颈和大转子较高的BMD值相关。在对体重进行调整后，胫骨和跟骨QUS与BMD的相关性有所改善且非常相似。这表明对体重进行校正很重要，并且可以增加QUS测量的预测价值。
